In the Depot, artefacts are stored on the basis of climatic requirements, rather than artistic movement or era. Each storage space is provided with a specific climate that is maintained by a climate control system. There are five different climate zones, suited to works of art produced with different materials: metal, plastic, organic/inorganic, black-and-white and colour photography. This method of storing the art collection calls for specific climatic conditions in which the air is not overly cold, warm, humid or dry.

Sustainability is an important feature in the design. The building includes many features to reduce the use of energy and water during its operation. A combination of geothermal heat exchange, solar panels, LED lighting, and high-performance insulation makes the building energy neutral with regards to building-related energy consumption. Rainwater is stored in the basement and used for irrigation and toilet facilities, reducing the building’s water consumption. This water storage, combined with the green roofs, makes water run-off minimal, with any remaining run-off directed into the pond of Het Nieuw Instituut, which is converted into a water basin for the surroundings. In this way, the Depot can be disconnected from the sewage system for rainwater.